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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2B2
All Species:
19.09
Human Site:
T184
Identified Species:
60
UniProt:
O14492
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14492
NP_066189
632
67738
T184
R
R
L
R
L
S
R
T
L
A
A
K
V
E
L
Chimpanzee
Pan troglodytes
XP_001144206
323
33769
Rhesus Macaque
Macaca mulatta
XP_001108503
637
68241
T188
R
R
L
R
L
S
R
T
L
A
A
K
V
E
L
Dog
Lupus familis
XP_546938
639
67478
T178
R
R
L
R
L
S
R
T
L
A
A
K
V
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JID9
621
66638
T177
R
R
L
R
L
A
R
T
L
A
A
K
V
E
L
Rat
Rattus norvegicus
Q9Z200
621
66689
T177
R
R
L
R
L
A
R
T
L
A
A
K
V
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506291
650
72002
S197
E
E
L
A
A
G
A
S
P
L
A
S
P
L
A
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624395
579
64607
G162
S
F
K
G
L
K
K
G
K
S
L
F
H
K
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
50.4
95.9
83.4
N.A.
82.9
83.3
N.A.
26.9
N.A.
N.A.
N.A.
N.A.
N.A.
27
N.A.
N.A.
Protein Similarity:
100
50.6
96.6
86.5
N.A.
86.3
87
N.A.
39.3
N.A.
N.A.
N.A.
N.A.
N.A.
42.2
N.A.
N.A.
P-Site Identity:
100
0
100
100
N.A.
93.3
93.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
0
100
100
N.A.
100
100
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
13
13
25
13
0
0
63
75
0
0
0
13
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
13
13
0
0
0
0
0
0
0
0
0
0
0
63
0
% E
% Phe:
0
13
0
0
0
0
0
0
0
0
0
13
0
0
0
% F
% Gly:
0
0
0
13
0
13
0
13
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
13
0
0
13
13
0
13
0
0
63
0
13
0
% K
% Leu:
0
0
75
0
75
0
0
0
63
13
13
0
0
13
63
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
13
0
0
0
13
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
13
% Q
% Arg:
63
63
0
63
0
0
63
0
0
0
0
0
0
0
0
% R
% Ser:
13
0
0
0
0
38
0
13
0
13
0
13
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
63
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
63
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _